By Klaus Ley
Inflammatory cellphone recruitment calls for the concerted motion of at the very least 5 significant units of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate constructions serving as selectin ligands, and sure ectoenzymes. This quantity offers a accomplished evaluate at the such a lot suitable leukocyte and endothelial adhesion molecules. The chapters are written through leaders within the box and concentrate on the biology, constitution, functionality, and legislation of adhesion molecules. at present authorized adhesion molecule-based remedies are reviewed and an outlook for destiny ways can be provided.
The booklet is of curiosity to clinicians and scientists from immunology, body structure, melanoma examine, rheumatology, allergology, infectious ailments, gastroenterology, pulmonology and cardiology.
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Additional resources for Adhesion Molecules: Function and Inhibition
J Biol Chem 273: 32506–32513 Croce K, Freedman SJ, Furie BC, Furie B (1998) Interaction between soluble P-selectin and soluble P-selectin glycoprotein ligand 1: Equilibrium binding analysis. Biochemistry 37: 16472–16480 Poppe L, Brown GS, Philo JS, Nikrad PV, Shah BH (1997) Conformation of sLex tetrasaccharide, free in solution and bound to E-, P-, and L-selectin. J Am Chem Soc 119: 1727–1736 Brandley BK, Kiso M, Abbas S, Nikrad P, Srivasatava O, Foxall C, Oda Y, Hasegawa A (1993) Structure-function studies on selectin carbohydrate ligands.
Selectin-ligand interactions are dynamic and involve the constant formation (Kon) and dissociation (Koff) of bonds depending on the shear forces exerted on the leukocyte due to the flow of blood. Forces above a specific threshold are required for the formation of functional tethers between Lselectin and its ligand [119, 120]. Importantly, L-selectin mediates rolling at faster velocities as compared to the other selectins implying that the Kon and Koff for Lselectin are higher than that for P- and E-selectin.
Blood 88: 2415–2421 Borges E, Tietz W, Steegmaier M, Moll T, Hallmann R, Hamann A, Vestweber D (1997) P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skin. J Exp Med 185: 573–578 Alon R, Fuhlbrigge RC, Finger EB, Springer TA (1996) Interactions through L-selectin between leukocytes and adherent leukocytes nucleate rolling adhesions on selectins and VCAM-1 in shear flow. J Cell Biol 135: 849–865 Wilkins PP, Moore KL, McEver RP, Cummings RD (1995) Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin.
Adhesion Molecules: Function and Inhibition by Klaus Ley