A critical review of the 2003 literature preceded by two by Gribble Gordon W. and Joule John A. (Eds.) PDF

By Gribble Gordon W. and Joule John A. (Eds.)

ISBN-10: 0080444822

ISBN-13: 9780080444826

This can be the 16th annual quantity of growth in Heterocyclic Chemistry, and covers the literature released in the course of 2003 on lots of the vital heterocyclic ring systems.This quantity opens with really expert studies. the 1st covers 'Lamellarins: Isolation, task and synthesis' an important workforce of biologically lively marine alkaloids and the second one discusses 'Radical Additions to Pyridines, Quinolines and Isoquinolines'. the remainder chapters learn the new literature at the universal heterocycles so as of accelerating ring dimension and the heteroatoms current.

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Extra info for A critical review of the 2003 literature preceded by two chapters on current heterocyclic topics

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M. F. J. Polak, J. Heterocycl. Chem. 1967, 4, 377. M. Dou, G. Vernin, J. Metzger, Tetrahedron Lett. 1968, 953. F. Minisci, R. Galli, M. Cecere, V. Malatesta, T. Caronna, Tetrahedron Lett. 1968, 5609. C. Bass, P. Nababsing, J. Chem. Soc. C 1970, 2169. G. M. Dou, J. Metzger, Bull. Soc. Chim. Fr. 1971, 2612. N. Hata, T. Saito, Bull. Chem. Soc. Jpn. 1973, 46, 942. F. Minisci, Synthesis 1973, 1. R. Bemardi, T. Caronna, R. Galli, F. Minisci, M. Perchinunno, Tetrahedron Lett. 1973, 645. F. Minisci, O.

C. J. 4:1 R pyridine 66-98% 19 R 16 18 Scheme 9 Curiously, concentration has also been found to influence the regiochemical course of such reactions. In the addition of phenyl radical to 4-methylpyridine, for example, Dou et al. <68TL953> found that at high dilution in nitrobenzene reactions were biased towards C2 addition. At higher concentrations, however, C3 addition predominated (Scheme 10). 2 Additions to Pyridinium and Quinolinium Salts Dou et aL <66BSF3815, 68TL953, 71BSF2612> went on to show that radical additions to pyridines, when conducted in acidic media, displayed enhanced selectivity towards C2 (Scheme 11).

Fujikawa, T. Fukuda, F. Ishibashi, Tetrahedron Lett. 2003, 44, 4443. P. Ploypradith, C. Mahidol, P. Sahakitpichan, S. Wongbundit, S. Ruchirawat, Angew. Chem. Int. Ed. 2004, 43, 866. C. Tardy, M. Facompre, W. Laine, B. Baldeyrou, D. Garcia-Gr~valos, A. Francesch, C. Mateo, A. A. Jim6nez, I. Manzanares, C. Cuevas, C. Bailly, Biorg. Med. Chem. 2004, 12, 1697. S. T. Handy, Y. Zhang, H. Bregman, J. Org. Chem. 2004, P. Cironi, M. ,/~lvarez, F. Albericio, QSAR & Comb. Sci. 2004, 23, 61. M. Marfil, F. /klvarez, Tetrahedron 2004, 60, 0000.

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A critical review of the 2003 literature preceded by two chapters on current heterocyclic topics by Gribble Gordon W. and Joule John A. (Eds.)

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