By John S. Bradley, John D. Nelson et al. (eds.)
New twenty first Edition! This bestselling and wide-spread source on pediatric antimicrobial therapy presents rapid entry to trustworthy, up to the moment options for remedy of all infectious illnesses in young children.
Practical, evidence-based ideas from the specialists in antimicrobial therapy
- Developed by means of unique editorial board
- Designed in case you look after childrens and are confronted with judgements each day
- New at-a-glance tables of bacterial and fungal pathogen susceptibilities to accepted antimicrobials
- New info on neonatal developmental pharmacology
- Includes remedy of parasitic infections and tropical medicine
- Updated tests in regards to the energy of the advice and the extent of facts for therapy ideas for significant infections
- Anti-infective drug directory, whole with formulations and dosages
- Antibiotic treatment for overweight children
- Antimicrobial prophylaxis/prevention of symptomatic infection
- Maximal grownup dosages and better dosages of a few antimicrobials typical in children
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Extra resources for 2015 Nelson's Pediatric Antimicrobial Therapy
Decolonization with mupirocin may also be helpful. Rat-bite fever (Streptobacillus moniliformis, Spirillum minus)34 Penicillin G 100,000–200,000 U/kg/day IV div q6h (BII) for 7–10 days; for endocarditis, ADD gentamicin for 4–6 wk (CIII). For mild disease, oral therapy with amox/clav (CIII). Organisms are normal oral flora for rodents. High rate of associated endocarditis. Alternatives: doxycycline; 2nd- and 3rd-generation cephalosporins (CIII). Staphylococcal scalded skin syndrome6,35 Standard: oxacillin 150 mg/kg/day IV div q6h OR cefazolin 100 mg/kg/day IV div q8h (CII) CA-MRSA: clindamycin 30 mg/kg/day IV div q8h (CIII) OR vancomycin 40 mg/kg/day IV q8h (CIII) Burow or Zephiran compresses for oozing skin and intertriginous areas.
ANTIMICROBIAL DOSAGES FOR NEONATES contLead author Jason Sauberan, assisted by the editors and John van der Anker Antibiotic Penicillin G benzathine Penicillin G crystalline (congenital syphilis) Penicillin G crystalline (GBS meningitis) Penicillin G procaine Route IM IV Piperacillin/tazobactam Rifampin Ticarcillin/clavulanate Valganciclovir Voriconazolep Zidovudine IV IV, PO IV PO IV, PO IV PO IV IM Dosages (mg/kg/day) and Intervals of Administration Chronologic Age ≤28 days Body Weight ≤2,000 g Body Weight >2,000 g 8–28 days old 0–7 days old 8–28 days olda 0–7 days old 50,000 U 50,000 U 50,000 U 50,000 U 100,000 U 150,000 U 100,000 U 150,000 U div q12h div q8h div q12h div q8h 200,000 U 300,000 U 300,000 U 400,000 U div q12h div q8h div q8h div q6h 50,000 U 50,000 U 50,000 U 50,000 U q24h q24h q24h q24h 300 div q8h 300 div q8h 320 div q6h 320 div q6h 10 q24h 10 q24h 10 q24h 10 q24h 150 div q12h 225 div q8h 150 div q12h 225 div q8h insufficient data insufficient data 32 div q12h 32 div q12h 16 div q12h 16 div q12h 16 div q12h 16 div q12h 3 div q12hp 6 div q12h 6 div q12h 3 div q12hq 4 div q12hp 8 div q12h 8 div q12h 4 div q12hq Chronologic Age 29–60 days 50,000 U 200,000 U div q6h 400,000 U div q6h 50,000 U q24h 320 div q6h 10 q24h 300 div q6h 32 div q12h 16 div q12h See Table A: HIV See Table A: HIV Use 0–7 days of age frequency until 14 days of age if birth weight <1,000 g.
Value of hyperbaric oxygen is not established (CIII). Focus definitive antimicrobial therapy based on culture results. Pyoderma, cutaneous abscesses (S aureus, including CA-MRSA; group A streptococcus)2,5–7,31–33 Standard: cephalexin 50–75 mg/kg/day PO div tid OR amox/clav 45 mg/kg/day PO div tid (BII) CA-MRSA: clindamycin 30 mg/kg/day PO div tid (BII) OR TMP/SMX 8 mg/kg/day of TMP PO div bid (CI) I&D when indicated; IV for serious infections. For prevention of recurrent CA-MRSA infection, use bleach baths daily (½ cup of bleach per full bathtub) (BII), OR bathe with chlorhexidine soap daily or qod.
2015 Nelson's Pediatric Antimicrobial Therapy by John S. Bradley, John D. Nelson et al. (eds.)